As the shouting over mandatory Covid-19 vaccination grows louder, as people cement their positions and refuse to budge, as dissenters are vilified, bullied, threatened and forced to get the shot or lose their jobs, and as some in their ranks discredit their cause, we are losing all perspective. Informed decisions – how to vote, what to say in conversation, whether to get vaccinated – require real knowledge. And while the sheer flow of information nowadays is infinite, the truth becomes more opaque and elusive. Welcome to C2C Journal’s special series on vaccines. It is aimed at offering a broad perspective in a calm delivery, in order to inform you and help you preserve your ability to think independently – the basis of individual freedom itself. In Part One, Lynne Cohen offers an appreciative overview of the struggles to develop some of history’s most important vaccines, and the remarkable individuals who stopped at nothing to get them done.